Description

2-Chloro-6-Fluorobenzylideneacetone is a versatile fluorinated and chlorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its unique molecular structure, featuring both halogen substituents and an α,β-unsaturated carbonyl group, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the halogenated aromatic core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials due to its conjugated system.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags and molecular probes for biochemical research.
• Custom Synthesis and Contract Manufacturing: A critical intermediate for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Chloro-6-Fluorobenzylideneacetone
CAS No.	175136-82-0
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	1-(2-Chloro-6-fluorophenyl)-3-buten-2-one; (E)-4-(2-Chloro-6-fluorophenyl)but-3-en-2-one; 2-Chloro-6-fluorobenzalacetone; 2-Chloro-6-fluoro-ω-chlorostyryl methyl ketone; 2-Chloro-6-fluorocinnamyl methyl ketone; (E)-1-(2-Chloro-6-fluorophenyl)but-2-en-1-one; 4-(2-Chloro-6-fluorophenyl)-3-buten-2-one
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluorobenzylideneacetone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by GC, HPLC, and NMR. Our quality protocols are designed to support cGMP and ISO standards for reliable scale-up from research to production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.