Description

3-(2-Chloro-3,4-Dimethoxyphenyl)Acrylonitrile is a high-purity, synthetically valuable acrylonitrile derivative characterized by its chloro and dimethoxy substituted aromatic ring. This compound serves as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis. It is primarily required by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging its functional group for molecular diversity.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Organic Synthesis Building Block: Employed in Heck reactions, cycloadditions, and other coupling reactions to introduce the acrylonitrile moiety into complex molecules.
• Ligand and Catalyst Development: Useful for creating novel ligands for metal catalysis or as a scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Fine Chemical Production: Intermediate for the manufacture of dyes, pigments, and other performance chemicals.

Basic Information

Product Name	3-(2-Chloro-3,4-Dimethoxyphenyl)Acrylonitrile
CAS No.	175136-03-5
Molecular Formula	C11H10ClNO2
Molecular Weight	223.66 g/mol
Synonyms	(E)-3-(2-Chloro-3,4-dimethoxyphenyl)acrylonitrile; 2-Chloro-3,4-dimethoxycinnamonitrile; 3-(2-Chloro-3,4-dimethoxyphenyl)-2-propenenitrile; trans-3-(2-Chloro-3,4-dimethoxyphenyl)acrylonitrile; Acrylonitrile, 3-(2-chloro-3,4-dimethoxyphenyl)-; (2E)-3-(2-Chloro-3,4-dimethoxyphenyl)prop-2-enenitrile
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-3,4-Dimethoxyphenyl)Acrylonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.