Description

Ethanone, 2,2,2-Trifluoro-1-(4-Methyl-2-Thiazolyl)- (9Ci) is a specialized fluorinated ketone building block featuring a trifluoroacetyl group linked to a substituted thiazole heterocycle. This compound matters as a high-value intermediate for synthesizing advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams working on novel active ingredients, including potential kinase inhibitors, antiviral agents, and crop protection chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, especially in oncology and antiviral research.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances efficacy and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers or liquid crystals that require specific electronic properties from the thiazole-fluorine combination.
• Chemical Biology & Proteomics: Can be utilized as a reactive handle or affinity tag in the design of chemical probes for target identification and validation.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, condensations, and nucleophilic additions to construct complex heterocyclic frameworks.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-(4-Methyl-2-Thiazolyl)- (9Ci)
CAS No.	174824-73-8
Molecular Formula	C6H4F3NOS
Molecular Weight	195.16 g/mol
Synonyms	1-(4-Methyl-2-thiazolyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-methyl-1,3-thiazol-2-yl)ethanone; 4-Methyl-2-trifluoroacetylthiazole; 2-Trifluoroacetyl-4-methylthiazole; 2,2,2-Trifluoro-1-(4-methyl-2-thiazolyl)ethanone; Trifluoroacetic acid 4-methylthiazol-2-yl ester; TAT (abbreviation)
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-(4-Methyl-2-Thiazolyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.