Description

5-(Trifluoromethyl)Benzo[C][1,2]Oxaborol-1(3H)-Ol is a high-value, heterocyclic organoboron compound featuring a fused benzoxaborole core with a trifluoromethyl substituent. This unique structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of boron-containing drug candidates, particularly protease inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Building block for developing new generation herbicides and fungicides with enhanced bioavailability and environmental profile.
• Materials Science: Used in the research and development of organic electronic materials, such as OLED emitters and charge transport layers.
• Cross-Coupling Reactions: Serves as a versatile organoboron reagent in Suzuki-Miyaura cross-coupling for constructing complex biaryl structures.
• Chemical Biology Probes: Utilized in the design of activity-based probes and sensors for studying enzymatic activity and biological pathways.
• Academic & Industrial R&D: Fundamental research compound for exploring new catalytic cycles and boron chemistry methodologies.

Basic Information

Product Name	5-(Trifluoromethyl)Benzo[C][1,2]Oxaborol-1(3H)-Ol
CAS No.	174671-50-2
Molecular Formula	C8H4BF3O2
Molecular Weight	199.92 g/mol
Synonyms	5-(Trifluoromethyl)-1,3-dihydro-2,1-benzoxaborol-1-ol; 5-(Trifluoromethyl)-1-hydroxy-1,3-dihydro-2,1-benzoxaborole; 5-(Trifluoromethyl)benzo[c][1,2]oxaborol-1-ol; 1-Hydroxy-5-(trifluoromethyl)-1,3-dihydro-2,1-benzoxaborole; 174671-50-2; Trifluoromethyl benzoxaborole; TFMB
EINECS	Contact for details

Quality Control

Every batch of 5-(Trifluoromethyl)Benzo[C][1,2]Oxaborol-1(3H)-Ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity requirements for research and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.