Description

6-Chloro-4-Fluoro-1-Indanone is a high-purity, synthetically valuable fluorinated and chlorinated indanone derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides and fungicides, leveraging the biological activity of the halogenated indanone scaffold.
• Organic Light-Emitting Diode (OLED) Materials: Acts as an electron-transport or host material precursor due to its rigid, planar structure and halogen substituents.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic frameworks with tailored electronic properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in cross-coupling, fluorination, and ring-forming reactions.

Basic Information

Product Name	6-Chloro-4-Fluoro-1-Indanone
CAS No.	174603-49-7
Molecular Formula	C9H6ClFO
Molecular Weight	184.59 g/mol
Synonyms	1-Indanone, 6-chloro-4-fluoro-; 6-Chloro-4-fluoroindan-1-one; 4-Fluoro-6-chloro-1-indanone; 6-Chloro-4-fluoro-2,3-dihydro-1H-inden-1-one; 174603-49-7; FC&I building block
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Fluoro-1-Indanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and consistent batch-to-batch reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for prolonged procedures to minimize risk of degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.