Description

(R)-A-Hydroxy-Cyclopropanepropanoic Acid CAS NO 174265-97-5 is a high-purity chiral building block featuring a cyclopropane ring and a carboxylic acid functional group. This compound is valued for its unique three-dimensional structure, which is critical for imparting specific biological activity and stereochemical control in advanced synthesis. It is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: The cyclopropane moiety is employed as a rigid scaffold in designing peptide mimics and bioisosteric replacements in medicinal chemistry.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry and drug discovery programs within university and corporate laboratories.

Basic Information

Product Name	(R)-A-Hydroxy-Cyclopropanepropanoic Acid
CAS No.	174265-97-5
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(R)-2-Hydroxy-2-cyclopropylacetic acid; (R)-2-Cyclopropyl-2-hydroxyacetic acid; (R)-α-Hydroxycyclopropaneacetic acid; (R)-Oxycyclopropaneacetic acid; (R)-HCPA; (R)-Cyclopropaneglycolic acid; (1R)-1-Hydroxycyclopropane-1-acetic acid
EINECS	Contact for details

Quality Control

Our (R)-A-Hydroxy-Cyclopropanepropanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request, supporting compliance with cGMP and other relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.