Description

(R)-2-Amino-3,3,3-trifluoro-1-propanol is a high-value, chiral fluorinated building block essential for modern synthetic chemistry. Its unique structure, featuring a trifluoromethyl group and a chiral amino alcohol moiety, makes it a critical intermediate for introducing fluorine atoms and stereochemistry into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Employed in the development of specialty polymers and advanced materials where fluorine incorporation modifies surface properties and stability.
• Fluorine Chemistry Research: A valuable standard and building block in academic and industrial laboratories exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	(R)-2-Amino-3,3,3-trifluoro-1-propanol
CAS No.	174075-83-3
Molecular Formula	C₃H₆F₃NO
Molecular Weight	129.08 g/mol
Synonyms	(R)-3-Amino-1,1,1-trifluoro-2-propanol; (R)-1,1,1-Trifluoro-3-amino-2-propanol; (R)-2-Amino-3,3,3-trifluoropropan-1-ol; (R)-3,3,3-Trifluoroalaninol; (R)-TFAP; (R)-TFAPro; (R)-Trifluoroalaninol; (R)-1-Amino-2-trifluoromethylethanol
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our chiral intermediates. Each batch of (R)-2-Amino-3,3,3-trifluoro-1-propanol is characterized and tested to ensure identity, purity, and enantiomeric excess meet exacting standards. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing key parameters such as assay, chiral purity (enantiomeric excess), and impurity profiles. Our quality system is designed to support cGMP and ISO compliant workflows for our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.