Description

2'-Fluoro-6'-(Trifluoromethyl)Acetophenone is a high-value, multi-fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluoro substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for CNS and oncology targets.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and pesticides where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals with unique electronic and surface properties.
• Fluorine Chemistry Studies: An important substrate for investigating novel fluorination reactions and reaction mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client projects.

Basic Information

Product Name	2'-Fluoro-6'-(Trifluoromethyl)Acetophenone
CAS No.	174013-29-7
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(2-Fluoro-6-(trifluoromethyl)phenyl)ethan-1-one; 2-Fluoro-α,α,α-trifluoroacetophenone; 2'-Fluoro-α,α,α-trifluoroacetophenone; 1-Acetyl-2-fluoro-3-(trifluoromethyl)benzene; 2-Fluoro-6-trifluoromethylacetophenone; 2-Fluoro-α,α,α-trifluoroacetophenone; 2'-Fluoro-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Fluro-6'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.