Description

1-(4-Bromophenyl)-2,2-Difluoroethanone is a high-purity, versatile aryl ketone building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions and as a precursor to fluorinated bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those incorporating difluoromethyl or trifluoromethyl groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the bromo and difluoroacetyl groups serve as handles for further functionalization.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are valuable.
• Cross-Coupling Reactions: The bromophenyl moiety makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Library Building: A fundamental reagent for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1-(4-Bromophenyl)-2,2-Difluoroethanone
CAS No.	173974-88-4
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	4'-Bromo-2,2-difluoroacetophenone; 2,2-Difluoro-1-(4-bromophenyl)ethanone; p-Bromophenyldifluoromethyl ketone; 1-(4-Bromophenyl)-2,2-difluoroethan-1-one; 4-Bromo-α,α-difluoroacetophenone; (4-Bromophenyl)difluoromethyl ketone; α,α-Difluoro-4'-bromoacetophenone
EINECS	Contact for details

Quality Control

Our 1-(4-Bromophenyl)-2,2-Difluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.