Description

4-Ethyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• Peptidomimetic Chemistry: The protected dicarboxylic acid and piperidine structure makes it valuable for creating conformationally constrained peptide analogs.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new synthetic routes for nitrogen-containing heterocycles.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for custom synthesis projects requiring high-purity, specialized building blocks.

Basic Information

Product Name	4-Ethyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	173933-71-6
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	1-tert-Butyl 4-ethyl piperidine-1,2-dicarboxylate; 1-(tert-Butoxycarbonyl)-4-ethylpiperidine-2-carboxylic acid; 4-Ethyl-1,2-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester; 4-Ethyl-2-piperidinecarboxylic acid 1-(1,1-dimethylethyl) ester; BOC-4-Ethyl-piperidine-2-carboxylic acid; 1-Boc-4-ethylpipecolic acid; (2S)-1-tert-Butyl 4-ethyl piperidine-1,2-dicarboxylate (for enantiopure form); 4-Ethyl-N-Boc-pipecolic acid
EINECS	Contact for details

Quality Control

Our 4-Ethyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiopure grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.