Description

Telithromycin CAS NO 173838-31-8 is a semi-synthetic ketolide antibiotic derived from erythromycin, specifically designed to combat respiratory tract infections caused by resistant bacterial strains. Its primary value lies in its potent activity against macrolide-resistant *Streptococcus pneumoniae* and atypical pathogens, making it a critical agent in the antimicrobial arsenal. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing formulations to treat community-acquired pneumonia, acute bacterial sinusitis, and chronic bronchitis.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of oral dosage forms, specifically tablets, for antibiotic therapies.
• Respiratory Infection Treatment: Formulation into drugs targeting community-acquired pneumonia (CAP), acute bacterial exacerbations of chronic bronchitis (ABECB), and acute bacterial sinusitis.
• Antibacterial Research: Serves as a key reference standard and intermediate in microbiological research and the development of novel ketolide antibiotics.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for treating bacterial infections in animals, subject to regional regulatory approvals.

Basic Information

Product Name	Telithromycin
CAS No.	173838-31-8
Molecular Formula	C43H65N5O10
Molecular Weight	812.00 g/mol
Synonyms	Ketek; HMR 3647; RU-66647; Telithromycinum; 11,12-Dideoxy-3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-6-O-methyl-3-oxo-12,11-(oxycarbonyl)[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]erythromycin; (3R,4S,5S,8R,10R,11R,12S,13R)-11-[[(2S,3S,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-3-[[(2R,4R,5S,6S)-5-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-10-ethyl-5-methoxy-6,8,12-trimethyl-1,7-dioxaspiro[2.13]hexadecane-9,14-dione
EINECS	Contact for details

Quality Control

Our Telithromycin is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing including HPLC for assay and purity, identification by spectroscopic methods (IR, NMR), and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation and maintain potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details
Microbial Limits	Complies with Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.