Description

(S)-3-Boc-Amino-1-Diazo-5-Methylthio-2-Pentanone is a high-purity, non-racemic chiral building block featuring a diazo and a Boc-protected amino functional group. This compound is critically important for the synthesis of complex, biologically active molecules, particularly in the development of novel pharmaceuticals and advanced agrochemicals. It is primarily sought after by research institutions, custom synthesis laboratories, and fine chemical manufacturers engaged in peptidomimetic drug discovery and the creation of specialized chemical libraries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of chiral β-amino acids and constrained peptides for drug discovery programs.
• Agrochemical Research: Building block for developing novel, chiral active ingredients with specific biological activity.
• Peptidomimetics: Used to construct peptide analogs where the diazo group enables further functionalization via cyclopropanation or C-H insertion reactions.
• Chemical Biology Probes: Serves as a versatile handle for labeling or cross-linking studies in proteomics and enzyme research.
• Asymmetric Synthesis: Employed in catalytic reactions to introduce chiral centers with high enantiomeric purity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.

Basic Information

Product Name	(S)-3-Boc-Amino-1-Diazo-5-Methylthio-2-Pentanone
CAS No.	173472-42-9
Molecular Formula	C11H19N3O3S
Molecular Weight	273.35 g/mol
Synonyms	(S)-1-Diazo-5-(methylthio)-3-[(tert-butoxycarbonyl)amino]-2-pentanone; (S)-3-((tert-Butoxycarbonyl)amino)-1-diazo-5-(methylthio)pentan-2-one; tert-Butyl N-[(2S)-1-diazo-4-(methylsulfanyl)-4-oxobutan-2-yl]carbamate; Boc-L-Dap(Mta)-diazoketone; (S)-Boc-Amino Diazo Methylthio Pentanone
EINECS	Contact for details

Quality Control

Every batch of (S)-3-Boc-Amino-1-Diazo-5-Methylthio-2-Pentanone is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and other critical parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.