Description

Hydroxy-Peg3-Sulfonic Acid CAS NO 173459-90-0 is a specialized bifunctional PEG derivative featuring a terminal sulfonic acid group and a hydroxyl group, separated by a triethylene glycol spacer. This unique structure makes it a valuable hydrophilic linker and functionalization agent for modifying biomolecules and surfaces to enhance solubility and introduce negative charge. It is primarily needed by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing advanced drug delivery systems, diagnostic reagents, and functional materials.

Application

• Bioconjugation Linker: Used to covalently attach peptides, proteins, or other biomolecules to surfaces, nanoparticles, or other molecules, improving aqueous solubility.
• Drug Delivery System Component: Serves as a functional PEG spacer in prodrugs and antibody-drug conjugates (ADCs) to modulate pharmacokinetics and release profiles.
• Surface Modification: Employed to introduce hydrophilic, negatively charged sulfonate groups onto materials (e.g., sensors, chromatography media) to reduce non-specific binding.
• Polymer Chemistry: Acts as a monomer or functional chain-transfer agent in the synthesis of specialty polymers with tailored hydrophilicity and ionic character.
• Diagnostic Reagent Synthesis: Utilized in the preparation of contrast agents, fluorescent probes, and assay components where solubility and charge are critical.
• Intermediate for Further Derivatization: The reactive hydroxyl and sulfonic acid groups provide handles for further chemical modification to create custom PEG-based reagents.

Basic Information

Product Name	Hydroxy-Peg3-Sulfonic Acid
CAS No.	173459-90-0
Molecular Formula	C8H18O8S
Molecular Weight	274.29 g/mol
Synonyms	3-(2-(2-Hydroxyethoxy)ethoxy)propane-1-sulfonic acid; 11-Hydroxy-3,6,9-trioxaundecane-1-sulfonic acid; HO-PEG3-Sulfonic Acid; 3,6,9-Trioxa-11-hydroxy-1-undecanesulfonic acid; Hydroxy-tri(ethylene glycol)-sulfonic acid; 2-[2-(2-Hydroxyethoxy)ethoxy]ethanesulfonic acid; PEG3-OH-Sulfonic Acid; 11-Hydroxyundecane-1-sulfonic acid, 3,6,9-trioxa-
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and mass spectrometry are provided to guarantee traceability and compliance with your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.