Description

1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-[2-[(2-Aminoethyl)Amino]-2-Oxoethyl]-,1,4,7-Tris(1,1-Dimethylethyl) Ester is a key protected intermediate in the synthesis of sophisticated macrocyclic chelating agents. This compound is critically important for researchers and manufacturers developing advanced contrast agents for medical imaging and targeted radiopharmaceuticals. It is primarily needed by pharmaceutical R&D teams, diagnostic imaging specialists, and fine chemical suppliers focused on high-value, complex molecular synthesis.

Application

• Precursor for MRI Contrast Agents: Serves as a protected intermediate in the synthesis of gadolinium-based macrocyclic complexes used in magnetic resonance imaging (MRI).
• Building Block for Radiopharmaceuticals: Used in the development of chelators for radiolabeling with isotopes like gallium-68 or lutetium-177 for positron emission tomography (PET) and targeted radiotherapy.
• Research & Development: A vital tool in academic and industrial labs for studying and creating new macrocyclic ligands with tailored properties.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex molecules requiring selective protection and deprotection strategies.
• Diagnostic Agent Development: Facilitates the creation of novel diagnostic probes for molecular imaging applications.

Basic Information

Item	Detail
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-[2-[(2-Aminoethyl)Amino]-2-Oxoethyl]-,1,4,7-Tris(1,1-Dimethylethyl) Ester
CAS No.	173308-19-5
Molecular Formula	C34H64N6O8
Molecular Weight	684.91 g/mol
Synonyms	DO3A-tris(t-butyl) ester-N'-aminoethylamide; 2,2',2''-(10-(2-((2-Aminoethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid tris(1,1-dimethylethyl) ester; tert-Butyl DO3A-NH-ethylamine; Protected DO3A-amine derivative; 1,4,7-Tris(tert-butoxycarbonylmethyl)-10-[N-(2-aminoethyl)carbamoylmethyl]-1,4,7,10-tetraazacyclododecane; DO3A-tBu-ester-NH-Et-NH2; Precursor for DOTA-tris(t-Bu ester)-NHS ester synthesis
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity, identity, and impurity profiles. While not a bulk active pharmaceutical ingredient (API), our quality systems are designed to support cGMP-compliant workflows for our customers in the pharmaceutical supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and performance in subsequent synthetic steps.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.