Description

Ethanone, 2-Chloro-2,2-Difluoro-1-(4-Methoxyphenyl)- (9Ci) is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoromethyl and chloro substituents, enabling precise molecular construction. This high-purity intermediate is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly those targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for fluorinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoro and chloro groups enhance biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials requiring specific dipole moments and stability.
• Advanced Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones, altering thermal and chemical resistance properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for biaryl formation.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research into new fluorination methodologies and the study of fluorine effects.

Basic Information

Product Name	Ethanone, 2-Chloro-2,2-Difluoro-1-(4-Methoxyphenyl)- (9Ci)
CAS No.	173067-08-8
Molecular Formula	C9H7ClF2O2
Molecular Weight	220.60 g/mol
Synonyms	2-Chloro-2,2-difluoro-1-(4-methoxyphenyl)ethanone; 1-(4-Methoxyphenyl)-2-chloro-2,2-difluoroethanone; 4-Methoxy-α,α-difluoro-α-chloroacetophenone; α-Chloro-α,α-difluoro-4-methoxyacetophenone; 2-Chloro-2,2-difluoro-1-(4-methoxyphenyl)ethan-1-one; p-Methoxyphenyl 2-chloro-2,2-difluoromethyl ketone; Difluorochloromethyl 4-methoxyphenyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-2,2-Difluoro-1-(4-Methoxyphenyl)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.