Description

2-(1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a versatile and high-value organoboron building block, specifically a benzonitrile-substituted cyclic boronic ester. This compound is critical for modern synthetic chemistry, enabling the formation of new carbon-carbon bonds through cross-coupling reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures, which are core scaffolds in many pharmaceuticals and organic electronic materials.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing a benzonitrile moiety.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or building block for polymers and organic semiconductors used in OLEDs and other electronic devices.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological processes and enzyme activity.

Basic Information

Item	Details
Product Name	2-(1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	172732-52-4
Molecular Formula	C10H10BNO2
Molecular Weight	187.01 g/mol
Synonyms	2-(1,3,2-Dioxaborolan-2-yl)benzonitrile; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (common structural analog name); 2-Cyanophenylboronic acid pinacol ester; Benzonitrile, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-(Pinacolboranyl)benzonitrile; 2-Boronobenzonitrile pinacol ester; o-Cyanophenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 2-(1,3,2-Dioxaborolan-2-Yl)Benzonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Every lot is characterized by advanced analytical techniques, including NMR and HPLC, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support cGMP manufacturing requirements for pharmaceutical customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.