Description

(S)-3-Fmoc-Amino-1-Diazo-3-Phenyl-2-Butanone is a specialized, high-purity chiral building block featuring both an Fmoc-protected amino group and a reactive diazo ketone moiety. This compound is critical for the synthesis of complex, stereochemically defined molecules, particularly in the development of novel pharmaceuticals and bioactive peptides. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for applications requiring precise molecular architecture.

Application

• Peptide Synthesis: Serves as a key intermediate for introducing non-natural amino acid residues and constructing conformationally constrained peptide analogs.
• Pharmaceutical Research: Used in the synthesis of potential drug candidates, especially protease inhibitors and receptor ligands where stereochemistry is crucial for activity.
• Chemical Biology Probes: Employed to create photoaffinity labeling agents or activity-based probes due to the reactive diazo functionality.
• Asymmetric Synthesis: Acts as a chiral synthon in the construction of complex natural products and other bioactive molecules.
• Material Science: Potential precursor for specialized polymers or dendrimers with tailored functional groups.

Basic Information

Product Name	(S)-3-Fmoc-Amino-1-Diazo-3-Phenyl-2-Butanone
CAS No.	172097-41-5
Molecular Formula	C25H21N3O3
Molecular Weight	411.46 g/mol
Synonyms	(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-diazo-3-phenylbutan-2-one; Fmoc-Asp(OMe)-diazoketone (S-isomer); (S)-3-(Fmoc-amino)-1-diazo-3-phenyl-2-butanone; (S)-1-Diazo-3-(Fmoc-amino)-3-phenyl-2-butanone; Fmoc-L-Aspartic acid β-methyl ester α-diazoketone; (S)-α-Diazo-β-keto ester derivative of Fmoc-Asp(OMe); 172097-41-5; (S)-3-[(9-Fluorenylmethoxycarbonyl)amino]-1-diazo-3-phenylbutan-2-one
EINECS	Contact for details

Quality Control

Our (S)-3-Fmoc-Amino-1-Diazo-3-Phenyl-2-Butanone is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity is provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. The compound is light-sensitive and should be handled under subdued lighting. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake and thermal degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.