Description

Benzo[B]Thiophene-3-Boronic Acid Pinacol Ester, 95% is a high-purity organoboron reagent, specifically a protected boronic acid derivative. This compound is a critical building block in modern synthetic chemistry, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing the benzothiophene scaffold, which is prevalent in drug discovery.
• Agrochemical Synthesis: Used to construct novel heterocyclic compounds for the development of new herbicides, fungicides, and insecticides.
• Material Science Research: Building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to the benzothiophene unit's electronic properties.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group offers enhanced stability, making this reagent ideal for palladium-catalyzed coupling reactions with various aryl halides to form biaryl structures.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	Benzo[B]Thiophene-3-Boronic Acid Pinacol Ester, 95%
CAS No.	171364-86-6
Molecular Formula	C₁₄H₁₇BO₂S
Molecular Weight	260.16 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]thiophene; Benzo[b]thiophen-3-ylboronic acid pinacol ester; 2-(Benzothiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Borono-benzo[b]thiophene pinacol ester; BTBP; Benzothiophene-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our Benzo[B]Thiophene-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to maintain stability and prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.