Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, versatile boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and R&D professionals developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex molecules in drug discovery and development, particularly for creating biaryl and heterobiaryl structures present in many APIs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aromatic frameworks.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs (Organic Light-Emitting Diodes) and semiconductors, where precise molecular architecture is crucial.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Polymer Chemistry: A monomer or cross-linking agent in the development of specialty polymers with tailored properties.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	171364-82-2
Molecular Formula	C13H16BNO2
Molecular Weight	229.09 g/mol
Synonyms	4-Cyanophenylboronic Acid Pinacol Ester; (4-Cyanophenyl)boronic Acid Pinacol Ester; 4-Cyanophenylboronic Acid, Pinacol Ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-(4-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-CN-PhBpin; p-Cyanophenylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques, including HPLC, GC, NMR, and LC-MS, for comprehensive characterization and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and conformance to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.