Description

5-Indolizinecarboxaldehyde, Octahydro-, (5S-Trans)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex nitrogen-containing heterocycles, which are core scaffolds in modern pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Asymmetric Catalysis Research: Serves as a precursor or ligand in the development of new chiral catalysts and auxiliaries for stereoselective transformations.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships by introducing the indolizine core into candidate molecules to modulate biological activity and pharmacokinetic properties.
• Agrochemical Synthesis: Employed in the synthesis of advanced, biologically active compounds for crop protection and pest management.
• Academic & Institutional Research: A valuable tool for synthetic methodology development and the study of heterocyclic chemistry in university and government laboratories.
• Fine Chemical Production: Integrated into multi-step synthesis pathways for producing specialty chemicals, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	5-Indolizinecarboxaldehyde, Octahydro-, (5S-Trans)- (9Ci)
CAS No.	171012-65-0
Molecular Formula	C9H15NO
Molecular Weight	153.22 g/mol
Synonyms	(5S-trans)-Octahydro-5-indolizinecarboxaldehyde; (5S,8aS)-Octahydroindolizine-5-carbaldehyde; (5S-trans)-Octahydroindolizine-5-carboxaldehyde; trans-(5S)-Octahydroindolizine-5-carbaldehyde; 5-Indolizinecarboxaldehyde, octahydro-, (5S-trans)-; (5S,8aS)-Octahydro-1H-indolizine-5-carbaldehyde; Chiral Octahydroindolizine Aldehyde; 171012-65-0
EINECS	Contact for details

Quality Control

Our 5-Indolizinecarboxaldehyde, Octahydro-, (5S-Trans)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation are provided to guarantee identity, purity, and lot-to-lot consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.