Description

Ethanone, 2,2-Difluoro-1-(5-Methyl-2-Furanyl)-2-(Methylthio)- (9Ci) is a specialized fluorinated organic building block featuring a unique furan-thioether-acetyl structural motif. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, where its distinct fluorine and sulfur atoms are leveraged to modulate biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation pesticides and herbicides, where the difluoro and methylthio groups can enhance bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for novel fluorinated polymers or liquid crystals, contributing to materials with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying enzyme mechanisms or protein-ligand interactions due to its reactive ketone and heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP for clinical trial materials.

Basic Information

Product Name	Ethanone, 2,2-Difluoro-1-(5-Methyl-2-Furanyl)-2-(Methylthio)- (9Ci)
CAS No.	170654-37-2
Molecular Formula	C8H8F2O2S
Molecular Weight	206.21 g/mol
Synonyms	2,2-Difluoro-1-(5-methyl-2-furanyl)-2-(methylthio)ethanone; 1-(5-Methyl-2-furanyl)-2,2-difluoro-2-(methylthio)ethanone; 2,2-Difluoro-2-(methylthio)-1-(5-methyl-2-furanyl)ethanone; 5-Methyl-2-furyl 2,2-difluoro-2-(methylthio)acetyl ketone; Difluoro(methylthio)acetyl-5-methylfuran; 170654-37-2 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of Ethanone, 2,2-Difluoro-1-(5-Methyl-2-Furanyl)-2-(Methylthio)- adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC-MS, and NMR for identity confirmation and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen) for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H & 19F NMR)
Purity (HPLC)	≥ 97.0% (Area Percent)
Assay (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.