Description

3,5-Difluoro-4-Methoxyacetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas where fluorinated motifs enhance bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro-methoxyacetophenone core contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to desired dielectric and optical properties.
• Advanced Polymer Chemistry: Employed as a monomer or modifier in the synthesis of specialty polymers with enhanced thermal and chemical resistance.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and method development in academic and industrial laboratories.
• Fluorine Chemistry Studies: Used as a model compound for investigating reaction pathways and properties of difluorinated aromatic systems.

Basic Information

Product Name	3,5-Difluoro-4-Methoxyacetophenone
CAS No.	170570-79-3
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1-(3,5-Difluoro-4-methoxyphenyl)ethan-1-one; 3',5'-Difluoro-4'-methoxyacetophenone; 4'-Methoxy-3',5'-difluoroacetophenone; 3,5-Difluoro-4-methoxyacetophenone; 3,5-Difluoro-4-methoxybenzene-1-yl methyl ketone; 3,5-Difluoro-4-methoxyphenyl methyl ketone; 3,5-Difluoro-4-methoxyacetylbenzene; 3,5-Difluoro-4-methoxy-1-acetylbenzene
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxyacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.