Description

3-Maleimidophenyl Boronic Acid is a high-purity, bifunctional organic compound that serves as a critical building block in advanced synthesis. Its unique structure, combining a maleimide group for thiol-specific conjugation and a boronic acid moiety for selective binding to diols, makes it indispensable for creating targeted molecular constructs. This reagent is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science industries for developing antibody-drug conjugates (ADCs), diagnostic probes, and functional polymers.

Application

• Bioconjugation Linker: A key reagent for site-specific conjugation in the development of Antibody-Drug Conjugates (ADCs) and other biopharmaceuticals.
• Chemical Biology Probes: Used to create activity-based probes and sensors for studying glycans, sugars, and other diol-containing biomolecules.
• Polymer Functionalization: Serves as a crosslinker or functional monomer for synthesizing smart polymers and hydrogels with responsive properties.
• Surface Immobilization: Enables the covalent attachment of biomolecules (like proteins or sugars) to maleimide-activated surfaces via the boronic acid handle.
• Solid-Phase Synthesis: Acts as a versatile building block in combinatorial chemistry and peptide synthesis on solid supports.
• Diagnostic Assay Development: Utilized in the fabrication of biosensors and diagnostic devices that require specific capture of cis-diol compounds.

Basic Information

Product Name	3-Maleimidophenyl Boronic Acid
CAS No.	170368-42-0
Molecular Formula	C10H8BNO4
Molecular Weight	217.00 g/mol
Synonyms	3-(Maleimido)phenylboronic Acid; 3-Maleimidobenzeneboronic Acid; Maleimidophenylboronic Acid; 3-MPBA; 3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)benzeneboronic Acid; 1-(3-Boronophenyl)-1H-pyrrole-2,5-dione; B-[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 3-Maleimidophenyl Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure consistency and traceability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.