Description

cis-Cyclopropanecarboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester is a high-purity, protected amino acid derivative featuring a cyclopropane ring, a key structural motif in advanced organic synthesis. This compound serves as a critical chiral building block for medicinal chemists, enabling the efficient construction of complex molecules with precise stereochemistry. It is primarily utilized in the research and development of pharmaceutical intermediates and novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring constrained peptide mimetics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting proteases and GPCRs.
• Peptidomimetic Synthesis: Used to introduce the rigid, conformationally-restricted cyclopropane scaffold into peptide backbones to enhance metabolic stability and binding affinity.
• Chiral Auxiliary/Building Block: Employed in asymmetric synthesis to construct stereogenic centers with high enantiomeric purity for complex natural products and agrochemicals.
• Chemical Biology Research: Utilized in the development of activity-based probes and molecular tools for studying enzyme function and biological pathways.
• Agrochemical Development: Acts as an intermediate in the creation of new pesticides and herbicides with improved efficacy and environmental profiles.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-quality, specialized amino acid derivatives.

Basic Information

Product Name	cis-Cyclopropanecarboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester
CAS No.	170299-60-2
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(1S,2R)-2-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic acid methyl ester; Methyl (1S,2R)-2-[(tert-butoxycarbonyl)amino]cyclopropanecarboxylate; Boc-(1S,2R)-2-Aminocyclopropanecarboxylic acid methyl ester; (1S,2R)-Methyl 2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate; cis-2-(Boc-amino)cyclopropanecarboxylic acid methyl ester; (1S,2R)-2-(Boc-amino)cyclopropanecarboxylic acid methyl ester; Methyl cis-2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate
EINECS	Contact for details

Quality Control

Our cis-Cyclopropanecarboxylic Acid, 2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure identity, purity, and enantiomeric excess meet exacting standards. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.