Description

3,4,5-Trifluoroiodobenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique combination of fluorine substituents and a reactive iodine handle, enabling precise cross-coupling reactions and the introduction of complex fluorinated motifs. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates via Suzuki-Miyaura, Stille, or other palladium-catalyzed cross-couplings.
• Agrochemical Synthesis: Used to construct fluorinated heterocycles and aromatic cores for next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of fluorine.
• Liquid Crystal & OLED Material Development: Serves as a building block for fluorinated organic semiconductors, charge-transport materials, and liquid crystal compounds in electronic displays.
• Positron Emission Tomography (PET) Tracer Precursor: Employed in radiochemistry for the synthesis of fluorine-18 labeled tracers, utilizing the iodine atom as a leaving group for nucleophilic aromatic substitution.
• Organic Synthesis Reagent: Facilitates the introduction of the 3,4,5-trifluorophenyl group into complex molecular architectures in academic and industrial R&D settings.
• Polymer & Material Science: Used to create fluorinated monomers and additives to impart specific properties like chemical resistance, thermal stability, or low surface energy to polymers.

Basic Information

Product Name	3,4,5-Trifluoroiodobenzene
CAS No.	170112-66-0
Molecular Formula	C6H2F3I
Molecular Weight	289.98 g/mol
Synonyms	1-Iodo-3,4,5-trifluorobenzene; 3,4,5-Trifluorophenyl iodide; 3,4,5-Trifluoro-1-iodobenzene; Benzene, 1-iodo-3,4,5-trifluoro-; Iodotrifluorobenzene (mixed isomers may be specified); 3,4,5-Trifluorobenzene, iodo-; 3,4,5-Trifluoroidobenzene
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluoroiodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.