Description

3-Fluoropyrrolidine Hydrochloride is a high-value fluorinated heterocyclic building block essential for modern pharmaceutical and agrochemical research. This compound serves as a key intermediate in the synthesis of bioactive molecules, particularly for the development of novel enzyme inhibitors and receptor modulators. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries to introduce the fluoropyrrolidine moiety, a privileged scaffold known to enhance metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Protease Inhibitor Development: Used in the research and production of inhibitors for proteolytic enzymes such as DPP-4, crucial for type 2 diabetes treatments.
• Agrochemical Synthesis: Serves as a precursor in creating advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Peptidomimetics & Bioisosteres: Employed to construct peptidomimetic compounds where the fluoropyrrolidine ring acts as a proline bioisostere, altering peptide conformation and stability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or functional additive in the development of specialized polymers and advanced materials.

Basic Information

Product Name	3-Fluoropyrrolidine Hydrochloride
CAS No.	169750-17-8
Molecular Formula	C₄H₈FN•HCl
Molecular Weight	125.57 (Free base) / 162.03 (HCl salt)
Synonyms	3-Fluoropyrrolidine HCl; 3-Fluoro-pyrrolidine hydrochloride; Pyrrolidine, 3-fluoro-, hydrochloride; 3-Fluoropyrrolidine Hydrochloride Salt; 3-Fluoropyrrolidinium Chloride; 3-Fluoroazolidine Hydrochloride; 3-Fluorotetrahydro-pyrrole Hydrochloride; (3R)-3-Fluoropyrrolidine Hydrochloride (for enantiopure form); (3S)-3-Fluoropyrrolidine Hydrochloride (for enantiopure form)
EINECS	Contact for details

Quality Control

Our 3-Fluoropyrrolidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.