Description

2,2,2-Trifluoro-1-(4-Methoxy-Naphthalen-1-Yl)-Ethanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoroacetyl group adjacent to a methoxynaphthalene scaffold, making it a critical intermediate for constructing complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where the introduction of fluorine atoms is desired to modulate biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, especially for incorporating the trifluoromethyl ketone moiety into target structures.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where fluorine substitution is leveraged to enhance efficacy and environmental profile.
• Material Science Research: Acts as a precursor for developing specialty polymers or organic electronic materials with tailored properties.
• Fluorine Chemistry Studies: Employed in academic and industrial laboratories to study the synthesis and reactivity of fluorinated aromatic compounds.
• Ligand and Catalyst Development: Utilized for constructing complex organic ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Incorporated into the multi-step synthesis of high-value, complex fine chemicals and flavors/fragrances.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-Methoxy-Naphthalen-1-Yl)-Ethanone
CAS No.	169295-54-9
Molecular Formula	C₁₃H₉F₃O₂
Molecular Weight	254.21 g/mol
Synonyms	1-(4-Methoxy-1-naphthyl)-2,2,2-trifluoroethanone; 4-Methoxy-1-naphthyl Trifluoromethyl Ketone; 2,2,2-Trifluoro-1-(4-methoxynaphthalen-1-yl)ethanone; 4-Methoxy-α,α,α-trifluoro-1-naphthaleneacetophenone; Trifluoro(4-methoxy-1-naphthyl)methanone; 1-(4-Methoxynaphthalen-1-yl)-2,2,2-trifluoroethan-1-one; 4-Methoxy-1-naphthoyltrifluoromethane
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(4-Methoxy-Naphthalen-1-Yl)-Ethanone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.