Description

Doyle Dirhodium Catalyst-Rh2(4S-Meox)4 is a chiral dirhodium(II) carboxylate complex, a highly specialized catalyst designed for asymmetric synthesis. Its value lies in enabling highly enantioselective cyclopropanation, C-H insertion, and other carbenoid transfer reactions critical for constructing complex chiral molecules. This catalyst is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking efficient routes to single-enantiomer intermediates and active ingredients.

Application

• Asymmetric Cyclopropanation: Key for synthesizing chiral cyclopropane rings, privileged structures in medicinal chemistry.
• Enantioselective C-H Amination: For the direct, catalytic conversion of C-H bonds into C-N bonds with high stereocontrol.
• Carbenoid Insertion Reactions: Enabling the formation of C-C and C-X bonds in complex molecule synthesis.
• Pharmaceutical Intermediate Synthesis: Production of chiral building blocks for drug candidates targeting CNS disorders, infectious diseases, and more.
• Agrochemical Active Ingredient Development: Creating enantiomerically pure herbicides, fungicides, and pesticides.
• Methodology Development in Academic & Industrial R&D: A staple tool for developing new asymmetric catalytic transformations.
• Fine Chemical and Fragrance Synthesis: For the production of high-value, optically active compounds.

Basic Information

Product Name	Doyle Dirhodium Catalyst-Rh2(4S-Meox)4
CAS No.	167693-36-9
Molecular Formula	C₂₈H₄₄N₄O₈Rh₂
Molecular Weight	751.48 g/mol
Synonyms	Dirhodium(II) tetrakis[(4S)-3-(1,3-dioxolan-2-ylmethyl)-4-isopropyl-2-oxazolidinone]; Rh₂(S-DOSP)₄; Dirhodium(II) (S)-DOSP; (S)-DOSP-Rh₂; Doyle Catalyst; Dirhodium(II) carboxylate catalyst; Chiral dirhodium catalyst; Rh₂(4S-MEOX)₄
EINECS	Contact for details

Quality Control

Every batch of our Doyle Dirhodium Catalyst is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral integrity, and performance in standard test reactions. Our quality commitment ensures the reproducibility and high catalytic activity required for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	Dark green to blue-green solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Rhodium Content	27.0 - 28.0 %
Solubility	Soluble in chlorinated solvents, DCM, toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.