Description

Methyl (1S,2S)-1-(1,3-Benzodioxol-5-Yl)-3-(2-Hydroxy-4-Methoxyphenyl)-5-Propoxyindane-2-Carboxylate is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral building block in the development of complex, biologically active molecules, offering precise structural control. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory research.
• Asymmetric Synthesis: Used as a starting material or advanced intermediate in catalytic asymmetric reactions to construct complex, enantiomerically pure targets.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize the biological profile of lead compounds.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant scale, focusing on yield and purity optimization.
• Reference Standard: Acts as an analytical standard for quality control and method validation in the production of related active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Item	Details
Product Name	Methyl (1S,2S)-1-(1,3-Benzodioxol-5-Yl)-3-(2-Hydroxy-4-Methoxyphenyl)-5-Propoxyindane-2-Carboxylate
CAS No.	167256-05-5
Molecular Formula	C28H28O7
Molecular Weight	476.52 g/mol
Synonyms	(1S,2S)-Methyl 1-(1,3-Benzodioxol-5-yl)-3-(2-hydroxy-4-methoxyphenyl)-5-propoxyindane-2-carboxylate; Methyl (1S-cis)-1-(1,3-benzodioxol-5-yl)-3-(2-hydroxy-4-methoxyphenyl)-5-propoxyindane-2-carboxylate; 167256-05-5; (1S,2S)-1-(Benzo[d][1,3]dioxol-5-yl)-3-(2-hydroxy-4-methoxyphenyl)-5-propoxyindane-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.