Description

3-(3,4-Difluoro-Phenyl)-Propionaldehyde is a versatile fluorinated aromatic aldehyde building block, essential for introducing the 3,4-difluorophenyl moiety into complex molecular architectures. Its primary value lies in its role as a key synthetic intermediate for the development of advanced pharmaceuticals and agrochemicals, where the fluorine atoms enhance metabolic stability and binding affinity. This high-purity intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and kinase inhibitors where the difluorophenyl group is a common pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its impact on molecular polarity and stability.
• Polymer & Resin Modifiers: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Research: A valuable reagent in academic and industrial research labs for exploring new C-C bond formation reactions and creating novel fluorinated compound libraries.
• Flavor & Fragrance Chemistry: Potential use as a starting material for synthesizing complex aromatic molecules used in high-value fragrance compositions.

Basic Information

Product Name	3-(3,4-Difluoro-Phenyl)-Propionaldehyde
CAS No.	166947-10-0
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	3-(3,4-Difluorophenyl)propanal; 3,4-Difluorophenylpropionaldehyde; 3-(3,4-Difluorophenyl)propionaldehyde; 3,4-Difluoro-β-phenylpropionaldehyde; 3-(3,4-Difluorophenyl)-1-propanal; 3,4-Difluorohydrocinnamaldehyde; (3,4-Difluorophenyl)propionaldehyde; 166947-10-0
EINECS	Contact for details

Quality Control

Our 3-(3,4-Difluoro-Phenyl)-Propionaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and REACH requirements for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.