Description

Ethanone, 2,2,2-Trifluoro-1-[2-(Methylthio)Phenyl]- (9Ci) CAS NO 166831-65-8 is a specialized fluorinated aromatic ketone building block, distinguished by its trifluoroacetyl and methylthio substituents. This compound matters for its role as a key intermediate in the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily needed by research and development chemists and process scale-up teams working on novel active ingredients, heterocyclic compounds, and materials with tailored electronic properties.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its unique electronic properties imparted by the fluorine and sulfur atoms.
• Chemical Research & Development: Employed as a versatile building block for constructing complex heterocycles, such as benzothiophenes or fluorinated analogs of bioactive molecules.
• Fluorine Chemistry: A valuable substrate for studying nucleophilic substitution and other reactions involving fluorinated carbonyl compounds.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-[2-(Methylthio)Phenyl]- (9Ci)
CAS No.	166831-65-8
Molecular Formula	C9H7F3OS
Molecular Weight	220.21 g/mol
Synonyms	2,2,2-Trifluoro-1-[2-(Methylthio)phenyl]ethanone; 2'-(Methylthio)-2,2,2-trifluoroacetophenone; 1-(2-Methylsulfanylphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(2-methylthiophenyl)ethan-1-one; α,α,α-Trifluoro-2'-(methylthio)acetophenone; TFMPA-MT (common abbreviation); [2-(Methylthio)phenyl]trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-[2-(Methylthio)Phenyl]- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for research and scale-up applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.