Description

Cyclopropanecarboxaldehyde, 2-(1,5-Hexadien-3-Ynyl)-, [1S-[1Alpha,2Alpha(Z)]]- (9Ci) is a specialized chiral aldehyde building block featuring a unique cyclopropane ring conjugated with diene and alkyne functionalities. This compound matters for its role as a key synthetic intermediate in the production of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for constructing novel molecular architectures, such as prostaglandin analogs and other fine chemicals. Its high reactivity profile makes it a valuable asset for advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of prostaglandin and prostacyclin analogs, which are important for cardiovascular and anti-inflammatory drug research.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its complex structure for targeted biological activity.
• Advanced Material Precursor: Serves as a building block for specialty polymers and liquid crystals due to its rigid cyclopropane core and unsaturated side chains.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in asymmetric synthesis and natural product total synthesis.
• Fine Chemical Manufacturing: Integral to the multi-step production of high-value, low-volume specialty chemicals for various industrial applications.

Basic Information

Item	Details
Product Name	Cyclopropanecarboxaldehyde, 2-(1,5-Hexadien-3-Ynyl)-, [1S-[1Alpha,2Alpha(Z)]]- (9Ci)
CAS No.	166762-25-0
Molecular Formula	C11H12O
Molecular Weight	160.21 g/mol
Synonyms	(1S,2S)-2-[(1Z)-Hexa-1,5-dien-3-yn-1-yl]cyclopropanecarboxaldehyde; (1S,2S)-2-[(1Z)-1,5-Hexadien-3-yn-1-yl]cyclopropanecarboxaldehyde; [1S-[1α,2α(Z)]]-2-(1,5-Hexadien-3-ynyl)cyclopropanecarboxaldehyde; Chiral Cyclopropane Aldehyde Derivative; Prostaglandin Intermediate; (Z)-Isomer of the specified aldehyde.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management protocols. We employ advanced analytical techniques including chiral HPLC, GC, and NMR to ensure high enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, it is recommended to store under an inert gas (argon or nitrogen) at 2-8°C. For long-term storage, keep at -20°C. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.