Description

(R)-(-)-1-[(S)-2-(Di(3,5-Bis-Trifluoromethylphenyl)Phosphino)Ferrocenyl]Ethyldi(3,5-Dimethylphenyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds. This advanced ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients and high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for synthesizing chiral amino acids, alcohols, and pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to create complex, stereodefined molecular architectures.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides where the biological activity is often specific to one enantiomer.
• Fine Chemical and Flavor/Fragrance Manufacturing: Enables the asymmetric synthesis of high-value chiral compounds used in flavors, fragrances, and advanced materials.
• Academic and Industrial R&D: A vital tool for methodology development and exploring new catalytic transformations in both academic laboratories and corporate R&D centers.

Basic Information

Item	Details
Product Name	(R)-(-)-1-[(S)-2-(Di(3,5-Bis-Trifluoromethylphenyl)Phosphino)Ferrocenyl]Ethyldi(3,5-Dimethylphenyl)Phosphine
CAS No.	166172-63-0
Molecular Formula	C51H40F12FeP2
Molecular Weight	974.64 g/mol
Synonyms	(R)-(-)-1-[(S)-2-(Di(3,5-Bis-Trifluoromethylphenyl)Phosphino)Ferrocenyl]Ethyldi(3,5-Dimethylphenyl)Phosphine; (R)-(-)-1-[(S)-2-(Bis(3,5-bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; (R)-1-[(S)-2-(Di(3,5-bis(trifluoromethyl)phenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; SL-J009-1; Chiral Josiphos ligand; Chiral ferrocenyl diphosphine ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure the highest standards of purity and chiral integrity, essential for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess. Our quality systems support development under cGMP guidelines for pharmaceutical applications, and we comply with relevant global chemical regulations including REACH.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation and light, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.