Description

2-Hydroxy-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzoic Acid, Methyl Ester is a specialized, high-purity chemical building block featuring a reactive diazirine photophore. This compound is engineered for precision applications where controlled cross-linking or labeling under mild UV light is required. It is an essential intermediate for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-quality reagents for photoaffinity labeling and bioconjugation.

Application

• Photoaffinity Labeling Probes: A critical reagent for synthesizing probes to study protein-ligand interactions, enzyme active sites, and biological target identification.
• Bioconjugation & Linker Chemistry: Serves as a versatile cross-linking agent for attaching reporter molecules (e.g., fluorophores, biotin) to biomolecules like proteins, peptides, and oligonucleotides.
• Chemical Biology Research: Used in the development of tools for mapping protein-protein interactions and understanding complex biological pathways in live cells.
• Pharmaceutical Intermediate: Employed in the synthesis of novel drug candidates, particularly where site-specific modification or tracking of drug distribution is needed.
• Materials Science: Utilized in surface modification and the creation of functionalized polymers with light-responsive properties.

Basic Information

Product Name	2-Hydroxy-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzoic Acid, Methyl Ester
CAS No.	165963-72-4
Molecular Formula	C11H7F3N2O3
Molecular Weight	272.18 g/mol
Synonyms	Methyl 2-Hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoate; 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]salicylic Acid Methyl Ester; 3-(Trifluoromethyl)-3H-diazirin-3-yl Benzoic Acid Derivative; TFD Methyl Ester; Photoaffinity Labeling Reagent 165963-72-4; Diazirine-Benzoate Crosslinker; Methyl 4-(3-(Trifluoromethyl)diazirin-3-yl)salicylate
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzoic Acid, Methyl Ester is manufactured and tested under strict quality management systems to ensure consistency and purity for sensitive research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee reliable performance in your critical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.