Description

2-Trimethylsilyl-1-Ethylboronic Acid Pinacol Ester is a high-purity, organosilicon-protected boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in its enhanced stability compared to unprotected boronic acids, facilitating handling and storage while remaining a potent reagent for cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds, widely used in the synthesis of complex biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a protected boronic acid synthon in the multi-step synthesis of drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research & Development: Employed in creating novel herbicides, fungicides, and insecticides that require specific aryl-alkyl linkages.
• Material Science & OLED Development: Used in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic displays.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic and imaging applications.
• Process Chemistry & Scale-up: Its stability makes it suitable for optimization and large-scale manufacturing processes in fine chemical production.

Basic Information

Product Name	2-Trimethylsilyl-1-Ethylboronic Acid Pinacol Ester
CAS No.	165904-20-1
Molecular Formula	C11H25BO2Si
Molecular Weight	228.22 g/mol
Synonyms	1-Ethyl-2-(trimethylsilyl)ethaneboronic Acid Pinacol Ester; (2-(Trimethylsilyl)ethyl)boronic Acid Pinacol Ester; 2-(Trimethylsilyl)ethylboronic Acid Pinacol Ester; TMS-Ethyl-Bpin; Pinacol [2-(Trimethylsilyl)ethyl]boronate; (2-Trimethylsilylethyl)boronic Acid Pinacol Ester; 2-Trimethylsilylethylboronic Acid Pinacol Ester; 1-Ethyl-2-trimethylsilylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilyl-1-Ethylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality management system supports compliance with cGMP and ISO standards for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for prolonged periods to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.