Description

4-Chloro-4,4-Difluoro-1-(4-Fluoro-Phenyl)-Butane-1,3-Dione is a high-purity fluorinated diketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and difluoro substituents on the same carbon, makes it a versatile precursor for introducing fluorinated motifs into complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated heterocycles and active pharmaceutical ingredients (APIs), leveraging fluorine's ability to modulate metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the difluoromethylene group can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with unique thermal, chemical, or surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel chelating ligands or metal complexes for catalytic applications.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluoroorganic compounds.

Basic Information

Product Name	4-Chloro-4,4-Difluoro-1-(4-Fluoro-Phenyl)-Butane-1,3-Dione
CAS No.	164342-74-9
Molecular Formula	C10H6ClF3O2
Molecular Weight	250.60 g/mol
Synonyms	4-Chloro-4,4-difluoro-1-(4-fluorophenyl)butane-1,3-dione; 1-(4-Fluorophenyl)-4-chloro-4,4-difluorobutane-1,3-dione; 4-Chloro-4,4-difluoro-1-(p-fluorophenyl)-1,3-butanedione; 4-Chloro-4,4-difluoro-1-(4'-fluorophenyl)-1,3-butanedione; 164342-74-9; p-Fluorophenyl 4-chloro-4,4-difluoroacetoacetate (tautomeric form)
EINECS	Contact for details

Quality Control

Our 4-Chloro-4,4-Difluoro-1-(4-Fluoro-Phenyl)-Butane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to supply chain transparency and traceability ensures you receive a product that meets your exacting R&D and scale-up requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.