Description

Terpendole C CAS NO 164323-42-6 is a complex indole-diterpene alkaloid, a member of the terpendole family of natural products. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity as a specific inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). It serves as a critical reference standard and building block for researchers in pharmaceutical development, agrochemical discovery, and advanced organic synthesis, enabling the study of lipid metabolism and the creation of novel bioactive molecules.

Application

• Pharmaceutical Research & Development: Used as a high-purity reference standard and pharmacological probe for studying ACAT inhibition, cholesterol metabolism, and related metabolic disorders.
• Biochemical Pathway Analysis: A key tool in enzymology and cell biology for elucidating the role of ACAT in lipid droplet formation and cellular cholesterol homeostasis.
• Agrochemical Discovery: Investigated as a lead compound or biosynthetic intermediate for developing novel fungicides or plant growth regulators, leveraging its natural product origin.
• Organic & Medicinal Chemistry: Serves as a sophisticated chiral scaffold or intermediate for the total synthesis of complex natural products and the development of new therapeutic agents.
• Academic Research: Employed in universities and research institutes for studies in natural product chemistry, chemical biology, and enzyme mechanism investigation.

Basic Information

Product Name	Terpendole C
CAS No.	164323-42-6
Molecular Formula	C29H35NO5
Molecular Weight	477.60 g/mol
Synonyms	Terpendole C; 13-Desoxyterpendole I; ACAT Inhibitor Terpendole C; (1S,2R,5S,7R,10R,11S,14S,15R,20S)-5,7,14-Trihydroxy-15-[(1S)-1-hydroxyethyl]-11,20-dimethyl-16-oxa-13-azatetracyclo[10.7.1.0²,¹⁰.0¹⁴,²⁰]icosa-3,8-diene-6,17-dione
EINECS	Contact for details

Quality Control

Our Terpendole C is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.