Description

Benzenamine, 3,4,5-Trifluoro-n-Hydroxy- (9Ci) is a high-purity, fluorinated aniline derivative of significant interest in advanced organic synthesis. This compound serves as a critical multifunctional building block, offering a unique combination of an amine group and a hydroxyl group on a trifluoromethyl-substituted benzene ring. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures. Its specific structure makes it valuable for modulating the physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Used in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing trifluoromethyl groups.
• Fluorinated Dye and Pigment Intermediate: Employed in the production of specialized colorants with improved lightfastness and chemical resistance.
• Academic and Contract Research: Essential reagent for methodological studies and exploratory chemistry in university and CRO laboratories worldwide.

Basic Information

Product Name	Benzenamine, 3,4,5-Trifluoro-n-Hydroxy- (9Ci)
CAS No.	163734-04-1
Molecular Formula	C7H5F3N1O1
Molecular Weight	179.12 g/mol
Synonyms	3,4,5-Trifluoro-2-hydroxyaniline; 2-Amino-3,4,5-trifluorophenol; 3,4,5-Trifluoro-2-aminophenol; 2-Hydroxy-3,4,5-trifluoroaniline; 3,4,5-Trifluoro-2-hydroxybenzenamine; 2-Amino-3,4,5-trifluorohydroxybenzene; (3,4,5-Trifluoro-2-hydroxyphenyl)amine
EINECS	Contact for details

Quality Control

Our Benzenamine, 3,4,5-Trifluoro-n-Hydroxy- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the stringent requirements of research and process development. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming specifications for purity, related substances, and residual solvents. Our commitment to consistent quality and supply reliability supports your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.