Description

2-Chloro-4,4,4-Trifluoro-1-Phenyl-Butane-1,3-Dione is a specialized fluorinated diketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a chloro and trifluoromethyl group, makes it a valuable precursor for synthesizing complex heterocycles and fluorinated compounds. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical industries, where the introduction of fluorine atoms is a key strategy for modulating the biological activity and metabolic stability of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated scaffolds to enhance potency, bioavailability, and metabolic resistance.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating fluorinated organic materials, including specialty polymers, liquid crystals, and electronic chemicals with unique properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development, exploring new reactions involving fluorinated β-diketones and their metal complexes.
• Ligand Precursor: Can be utilized to synthesize chelating ligands for catalysis, taking advantage of the diketone moiety's ability to coordinate to various metals.

Basic Information

Item	Details
Product Name	2-Chloro-4,4,4-Trifluoro-1-Phenyl-Butane-1,3-Dione
CAS No.	163667-29-6
Molecular Formula	C10H6ClF3O2
Molecular Weight	250.60 g/mol
Synonyms	2-Chloro-4,4,4-trifluoro-1-phenylbutane-1,3-dione; 2-Chloro-4,4,4-trifluoro-1-phenyl-1,3-butanedione; 1-Phenyl-2-chloro-4,4,4-trifluorobutane-1,3-dione; 4,4,4-Trifluoro-2-chloro-1-phenyl-1,3-butanedione; 2-Chloro-4,4,4-trifluoro-1-phenylbutanedione; β-Chloro-β'-phenyl-4,4,4-trifluoroacetylacetone; Chloro(phenyl)(trifluoroacetyl)methane (variation)
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,4,4-Trifluoro-1-Phenyl-Butane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.