Description

4 - (2 - ((Tetrahydro - 2H - Pyran - 2 - Yl)Oxy)Ethyl)Benzaldehyde is a versatile and high-value protected aldehyde intermediate used in advanced organic synthesis. Its core value lies in the strategic protection of the reactive aldehyde group, enabling complex, multi-step reactions crucial for pharmaceutical and fine chemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key protected synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and metabolic disorders.
• Agrochemical Synthesis: Serves as a crucial building block for developing advanced herbicides, fungicides, and plant growth regulators with specific activity profiles.
• Liquid Crystal & OLED Material Precursor: Used in the research and production of organic electronic materials, where its aromatic and ether functionalities contribute to desired electronic properties.
• Peptide & Carbohydrate Chemistry: Employed in the synthesis of complex biomolecules and glycoconjugates, where the THP-protected hydroxyl group offers orthogonal protection strategies.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions, such as Suzuki or Heck couplings, to create extended conjugated systems for material science applications.
• Asymmetric Synthesis: Utilized as a chiral pool derivative or precursor for chiral auxiliaries and ligands in enantioselective catalysis.

Basic Information

Product Name	4 - (2 - ((Tetrahydro - 2H - Pyran - 2 - Yl)Oxy)Ethyl)Benzaldehyde
CAS No.	163164-46-3
Molecular Formula	C₁₄H₁₈O₃
Molecular Weight	234.29 g/mol
Synonyms	4-[2-(Tetrahydro-2H-pyran-2-yloxy)ethyl]benzaldehyde; 4-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzaldehyde; Benzaldehyde, 4-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-; 4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethyl)benzaldehyde; THP-protected 4-(2-Hydroxyethyl)benzaldehyde; 4-(2-Hydroxyethyl)benzaldehyde THP ether; p-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our 4 - (2 - ((Tetrahydro - 2H - Pyran - 2 - Yl)Oxy)Ethyl)Benzaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as nitrogen or argon to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.