Description

Ethanone, 1-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2,2,2-Trifluoro-, (R)- (9Ci) is a high-value, chiral trifluoromethyl ketone derivative, serving as a critical chiral building block in advanced organic synthesis. Its significance lies in its ability to introduce the trifluoromethyl group and a protected diol moiety with high stereochemical fidelity, enabling the construction of complex molecules with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of advanced, fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in asymmetric catalytic reactions to create enantiomerically pure compounds.
• Material Science Research: Acts as a building block for novel fluorinated polymers and liquid crystals with unique properties.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	Ethanone, 1-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2,2,2-Trifluoro-, (R)- (9Ci)
CAS No.	162932-23-2
Molecular Formula	C7H9F3O3
Molecular Weight	198.14 g/mol
Synonyms	(R)-1-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2,2-trifluoroethanone; (4R)-1-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2,2-trifluoroethanone; (R)-2,2,2-Trifluoro-1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanone; (R)-Trifluoroacetylglycerol Acetonide; (R)-TAG Acetonide; (R)-1,2-Isopropylidene-3-O-trifluoroacetyl-sn-glycerol; (R)-1,2-O-Isopropylidene-3-O-trifluoroacetyl-sn-glycerol; (R)-3-O-Trifluoroacetyl-1,2-O-isopropylidene-sn-glycerol
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2,2,2-Trifluoro-, (R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are sealed when not in use and stored away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.