Description

3-Azabicyclo[4.2.0]Octan-8-Amine,(1Alpha,6Alpha,8Beta)-(-)-(9Ci) is a high-purity, stereochemically defined bicyclic amine building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel, complex pharmaceutical molecules, particularly those targeting the central nervous system. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical and agrochemical industries seeking to incorporate rigid, nitrogen-containing scaffolds into their active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides where its unique bicyclic structure can impart specific biological activity.
• Asymmetric Synthesis: Serves as a sophisticated starting material or chiral auxiliary in catalytic asymmetric reactions to create enantiomerically pure products.
• Medicinal Chemistry SAR Studies: Employed to explore structure-activity relationships (SAR) by introducing a conformationally restricted amine moiety into lead compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or receptor interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized intermediates.

Basic Information

Product Name	3-Azabicyclo[4.2.0]Octan-8-Amine,(1Alpha,6Alpha,8Beta)-(-)-(9Ci)
CAS No.	162301-35-1
Molecular Formula	C7H14N2
Molecular Weight	126.20 g/mol
Synonyms	(1α,6α,8β)-3-Azabicyclo[4.2.0]octan-8-amine; (-)-(1α,6α,8β)-3-Azabicyclo[4.2.0]octan-8-amine; (1R,6R,8S)-3-Azabicyclo[4.2.0]octan-8-amine; Bicyclo[4.2.0]octan-8-amine, 3-aza-, (1α,6α,8β)-(-)-; 3-Azabicyclo[4.2.0]octan-8-amine, (1α,6α,8β)-(-)-; 162301-35-1; (1Alpha,6Alpha,8Beta)-3-Azabicyclo[4.2.0]octan-8-Amine
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[4.2.0]Octan-8-Amine,(1Alpha,6Alpha,8Beta)-(-)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.