Description

3'-Bromo-2'-Fluoroacetophenone is a high-purity fluorinated and brominated aromatic ketone building block. This compound is valued for its dual halogen functionality, which provides distinct reactivity for selective chemical transformations. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the preparation of advanced intermediates for crop protection agents, leveraging its halogenated structure for bioactivity.
• Chemical Research: Serves as a versatile building block in organic synthesis for introducing both bromo and fluoro substituents onto aromatic systems via further functionalization.
• Material Science Precursor: Potential use in the synthesis of specialty monomers or ligands for advanced polymeric materials and catalysts.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3'-Bromo-2'-Fluoroacetophenone
CAS No.	161957-61-5
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	1-(3-Bromo-2-fluorophenyl)ethan-1-one; 3-Bromo-2-fluoroacetophenone; 2-Fluoro-3-bromoacetophenone; 1-Acetyl-3-bromo-2-fluorobenzene; Ethanone, 1-(3-bromo-2-fluorophenyl)-; 3-Bromo-2-fluorophenyl methyl ketone; α-Bromo-α-fluoroacetophenone derivative (contextual)
EINECS	Contact for details

Quality Control

Our 3'-Bromo-2'-Fluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Melting Point	Reported value
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.