Description

3'-Chloro-2'-Fluoroacetophenone is a high-purity fluorinated and chlorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique halogenated structure makes it a critical intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers engaged in creating active pharmaceutical ingredients (APIs), liquid crystal materials, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where halogenated aromatic rings enhance biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the development of electron-transport materials and other functional layers in OLED devices.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to build complex biaryl systems.
• Fine Chemical Research: Utilized in academic and industrial R&D for exploring new fluorination methodologies and constructing diverse chemical libraries.

Basic Information

Product Name	3'-Chloro-2'-Fluoroacetophenone
CAS No.	161957-59-1
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	1-(3-Chloro-2-fluorophenyl)ethanone; 3-Chloro-2-fluoroacetophenone; 2-Fluoro-3-chloroacetophenone; 1-(3-Chloro-2-fluorophenyl)ethan-1-one; 2'-Fluoro-3'-chloroacetophenone; α-Chloro-α-fluoroacetophenone (isomer specific); Acetophenone, 3'-chloro-2'-fluoro-; Ethanone, 1-(3-chloro-2-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3'-Chloro-2'-Fluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.