Description

1-(2-Chloro-3-Fluorophenyl)Ethanone is a high-purity fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the chloro-fluoro substitution pattern enhances biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and studying structure-activity relationships (SAR) in medicinal chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	1-(2-Chloro-3-Fluorophenyl)Ethanone
CAS No.	161957-57-9
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	2'-Chloro-3'-fluoroacetophenone; 2-Chloro-3-fluoroacetophenone; 1-Acetyl-2-chloro-3-fluorobenzene; 2-Chloro-3-fluorophenyl methyl ketone; (2-Chloro-3-fluorophenyl)ethan-1-one; Ethanone, 1-(2-chloro-3-fluorophenyl)-; 2-Chloro-3-fluoroacetophenone
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-3-Fluorophenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.