Description

Perfluorophenyl Methanesulfonate is a specialized fluorinated building block and reagent of significant importance in advanced organic synthesis. Its core value lies in its highly reactive methanesulfonate (mesylate) group attached to an electron-deficient perfluorinated aromatic ring, making it an excellent electrophile for nucleophilic aromatic substitution and cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise fluorination and functionalization of complex molecules.

Application

• Pharmaceutical Intermediate: Key reagent for introducing the perfluorophenyl moiety into active pharmaceutical ingredients (APIs), particularly in the synthesis of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the perfluorophenyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical building block for fluorinated aromatic components in electronic display and lighting materials.
• Polymer & Resin Modification: Employed to incorporate fluorinated aromatic units into high-performance polymers, improving their thermal stability and chemical resistance.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated mesylate group facilitates displacement by various nucleophiles (amines, alkoxides, thiols) under mild conditions.
• Fluorinated Probe & Dye Synthesis: Utilized in the preparation of fluorinated tags and dyes for bioimaging and diagnostic applications.
• Chemical Research & Development: A versatile tool for exploring new synthetic methodologies and creating novel fluorinated compounds in academic and industrial R&D settings.

Basic Information

Product Name	Perfluorophenyl Methanesulfonate
CAS No.	161912-36-3
Molecular Formula	C7H3F5O3S
Molecular Weight	262.15 g/mol
Synonyms	Pentafluorophenyl Methanesulfonate; Methanesulfonic Acid Pentafluorophenyl Ester; Pentafluorophenyl Mesylate; 2,3,4,5,6-Pentafluorophenyl Methanesulfonate; Perfluorophenyl Mesylate; C6F5OSO2CH3; PFPM; Pentafluorophenyl Methanesulphonate
EINECS	Contact for details

Quality Control

Our Perfluorophenyl Methanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of pharmaceutical and advanced material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent hydrolysis and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.