Description

3-(4-Bromophenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated aromatic ketone building block, recognized for its unique trifluoromethyl ketone moiety and bromine substituent, which provide versatile reactivity for advanced synthesis. This compound is essential for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity. Its primary utility lies in serving as a key intermediate in medicinal chemistry, facilitating the construction of complex molecules for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers and liquid crystals with unique optical and electronic properties.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a substrate for developing new fluorination methodologies and asymmetric catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and inhibitors for studying enzyme mechanisms and protein function.

Basic Information

Product Name	3-(4-Bromophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	161809-64-9
Molecular Formula	C9H6BrF3O
Molecular Weight	267.04 g/mol
Synonyms	1-(4-Bromophenyl)-3,3,3-trifluoropropan-1-one; 4'-Bromo-3,3,3-trifluoropropiophenone; 4-Bromophenyl Trifluoroacetone; p-Bromophenyl Trifluoromethyl Ketone; 3,3,3-Trifluoro-1-(4-bromophenyl)-1-propanone; α,α,α-Trifluoro-4'-bromopropiophenone; 161809-64-9; 4-Bromo-α,α,α-trifluoroacetophenone (common misnomer, structurally related)
EINECS	Contact for details

Quality Control

Our production of 3-(4-Bromophenyl)-1,1,1-Trifluoro-2-Propanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.