Description

Boc-n-Methyl-D-Norleucine CAS NO 161450-84-6 is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a methyl group on the nitrogen. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure and function. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in oncology and metabolic disease research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified norleucine residues, enhancing peptide stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of selective enzyme inhibitors.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the creation of labeled peptide probes for diagnostic applications.
• Fine Chemical Synthesis: Acts as a versatile building block for constructing complex organic molecules with specific stereochemical requirements.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and organic synthesis methodologies.

Basic Information

Product Name	Boc-n-Methyl-D-Norleucine
CAS No.	161450-84-6
Molecular Formula	C₁₃H₂₅NO₄
Molecular Weight	259.34 g/mol
Synonyms	N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-D-norleucine; (R)-2-((tert-Butoxycarbonyl)(methyl)amino)hexanoic acid; Boc-N-Me-D-Nle-OH; Boc-N-Methyl-D-2-aminohexanoic acid; D-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-; N-Boc-N-methyl-D-norleucine; tert-Butyl (R)-(1-(methoxycarbonyl)pentyl)(methyl)carbamate (related ester); Boc-D-N-Me-Nle
EINECS	Contact for details

Quality Control

Every batch of Boc-n-Methyl-D-Norleucine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity requirements typical for pharmaceutical R&D applications. A Certificate of Analysis (COA) detailing specific results for assay, chiral purity, and related substances is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.