Description

(2S)-4-Oxo-1-(9-Phenylfluorenyl)-Proline Methyl Ester is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive compounds. It is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require high-quality, enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Serves as a versatile building block in catalytic asymmetric reactions for constructing stereogenic centers.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for complex organic molecules under Good Manufacturing Practice (GMP) conditions where applicable.

Basic Information

Product Name	(2S)-4-Oxo-1-(9-Phenylfluorenyl)-Proline Methyl Ester
CAS No.	160882-76-8
Molecular Formula	C26H21NO3
Molecular Weight	395.45 g/mol
Synonyms	1-(9H-Fluoren-9-yl)-L-proline, 4-oxo-, methyl ester; Methyl (2S)-4-oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate; (S)-1-(9-Phenyl-9H-fluoren-9-yl)-4-oxopyrrolidine-2-carboxylic acid methyl ester; Fmoc-Pro(4-oxo)-OMe (phenyl variant); 9-Phenylfluoren-9-yl protected 4-oxoproline methyl ester; (S)-4-Oxo-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylic acid methyl ester; N-(9-Phenylfluoren-9-yl)-4-oxo-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our (2S)-4-Oxo-1-(9-Phenylfluorenyl)-Proline Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Production adheres to cGMP guidelines where applicable, and all materials are supported by comprehensive analytical documentation. A Certificate of Analysis (COA) is provided with each shipment, detailing purity, chiral purity, and impurity profiles as determined by HPLC, NMR, and other relevant spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.