Description

4-((tert-Butyldimethylsilyloxy)Methyl)Benzaldehyde is a high-value, protected benzaldehyde derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound is a critical advanced pharmaceutical intermediate and a versatile synthetic building block for constructing complex organic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Peptide & Protein Chemistry: Serves as a protected aldehyde precursor for the introduction of aromatic aldehydes into peptides or for use in bioconjugation strategies.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific aromatic aldehyde functionalities.
• Liquid Crystal & OLED Material Precursor: Used in the synthesis of organic semiconductors, liquid crystal display (LCD) components, and light-emitting materials for electronic devices.
• Cross-Coupling Reactions: The aldehyde group and protected benzylic position make it a suitable substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Asymmetric Synthesis: Chiral auxiliary or starting material for the preparation of enantiomerically pure compounds via asymmetric induction.
• Polymer & Resin Modification: Functional monomer for creating specialty polymers with tailored thermal, mechanical, or optical properties.
• Organic Synthesis Research: A versatile reagent in academic and industrial research labs for exploring new synthetic methodologies and constructing complex molecular architectures.

Basic Information

Item	Details
Product Name	4-((tert-Butyldimethylsilyloxy)Methyl)Benzaldehyde
CAS No.	160744-60-5
Molecular Formula	C14H22O2Si
Molecular Weight	250.41 g/mol
Synonyms	4-((tert-Butyldimethylsilyloxy)methyl)benzaldehyde; 4-[(tert-Butyldimethylsilyloxy)methyl]benzaldehyde; p-((tert-Butyldimethylsilyloxy)methyl)benzaldehyde; 4-(Hydroxymethyl)benzaldehyde TBDMS ether; 4-Formylbenzyloxy-tert-butyldimethylsilane; TBDMS ether of 4-Hydroxymethylbenzaldehyde; 4-(TBDMS-oxymethyl)benzaldehyde; Benzaldehyde, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-
EINECS	Contact for details

Quality Control

Our 4-((tert-Butyldimethylsilyloxy)Methyl)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maximize stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.